Sahar A. Saddoughi

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis

Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson et al. · EMBO Molecular Medicine · 2012 · 265 citations · Full text

Life Sciences, Oncology, Pharmacology +17

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

Paolo Neviani, Jason G. Harb, Joshua J. Oaks et al. · Journal of Clinical Investigation · 2013 · 219 citations · Full text

Medicine, Oncology, Pharmacology +16

Direct interaction between the inhibitor 2 and ceramide <i>via</i> sphingolipid‐protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

Archana Mukhopadhyay, Sahar A. Saddoughi, Pengfei Song et al. · The FASEB Journal · 2008 · 205 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network

Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich et al. · Journal of Biological Chemistry · 2011 · 135 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A

Arelis Salas, Suriyan Ponnusamy, Can E. Senkal et al. · Blood · 2011 · 117 citations · Full text

Life Sciences, Cell Biology, Oncology +17