Gareth K. Jennings

Evidence for an Elevated Aspartate pK in the Active Site of Human Aromatase

Giovanna Di Nardo, Maximilian Breitner, Andrea Bandino et al. · Journal of Biological Chemistry · 2014 · 63 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

Anjan Debnath, Cláudia M. Calvet, Gareth K. Jennings et al. · PLoS neglected tropical diseases · 2017 · 59 citations · Full text

Pharmacy, Pharmacotherapy, Drug Discovery +14

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

Wenxu Zhou, Anjan Debnath, Gareth K. Jennings et al. · PLoS Pathogens · 2018 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast

Sabine Ottilie, Gregory M. Goldgof, Cláudia M. Calvet et al. · ACS Chemical Biology · 2016 · 33 citations

Life Sciences, Molecular Biology, Pharmacology +15

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1<i>H</i>-pyrrolyl)(phenyl)methyl-1<i>H</i>-imidazole Derivatives as Antiprotozoal Agents

Francesco Saccoliti, Valentina Noemi Madia, Valeria Tudino et al. · Journal of Medicinal Chemistry · 2019 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17