Misaki Homma

Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration

Hiroyuki Katayama, Hiroshi Hama, Koji Nagasawa et al. · Cell · 2020 · 176 citations · Full text

Life Sciences, Cell Biology, Neuroscience +14

Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins

Yuta Tanaka, Katsuji Aikawa, Goushi Nishida et al. · Journal of Medicinal Chemistry · 2013 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

Kenichi Iwai, Tadahiro Nambu, Ryo Dairiki et al. · Science Advances · 2019 · 70 citations · Full text

Medicine, Oncology, Pharmacology +6

Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-<i>d</i>]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent

Osamu Kurasawa, T. Miyazaki, Misaki Homma et al. · Journal of Medicinal Chemistry · 2020 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones

Osamu Kurasawa, Yuya Oguro, T. Miyazaki et al. · Bioorganic & Medicinal Chemistry · 2017 · 16 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17