Kv1.3 channel‐blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

Sandeep Chhabra, Shih Chieh Chang, Hai M. Nguyen, +19

The FASEB Journal

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Harunur Rashid, Redwan Huq, Mark R. Tanner, +9

Scientific Reports

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, +6

Clinical Immunology

InflammationRheumatologyRheumatoid DisorderAnti-inflammatoryPegylated Analog +10

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

Jennifer L. Johnson, Loredana Elena Stoica, Yuwei Liu, +28

Neuron

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

Michael W. Pennington, Shih Yu Chang, Satendra Chauhan, +5

Marine Drugs

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

M. Harunur Rashid, Germano Heinzelmann, Redwan Huq, +7

PLoS ONE

Free EnergyBiophysical ModelingPeptide EngineeringMolecular BiologyHyperpolarization (Biology) +16

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

Shyny Koshy, Redwan Huq, Mark R. Tanner, +7

Journal of Biological Chemistry

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

Shyny Koshy, Danli Wu, Xueyou Hu, +7

PLoS ONE

Adaptive Immune SystemApoptosisImmunologyNk CellsCell Death +16

Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation

Redwan Huq, Errol L. G. Samuel, William K. A. Sikkema, +11

Scientific Reports

KCa1.1 Inhibition Attenuates Fibroblast‐like Synoviocyte Invasiveness and Ameliorates Disease in Rat Models of Rheumatoid Arthritis

Mark R. Tanner, Xueyou Hu, Redwan Huq, +7

Arthritis & Rheumatology