Kyoko Shimano

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

Hirotoshi Kataoka, Kunio Sugahara, Kyoko Shimano et al. · PubMed · 2005 · 218 citations

Life Sciences, Immunology, Neuroscience +16

Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3

Yasuhiro Maeda, Hirofumi Matsuyuki, Kyoko Shimano et al. · The Journal of Immunology · 2007 · 135 citations

Life Sciences, Cell Biology, Immunology +17

Amiselimod, a novel sphingosine 1‐phosphate receptor‐1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

Kunio Sugahara, Yasuhiro Maeda, Kyoko Shimano et al. · British Journal of Pharmacology · 2016 · 86 citations · Full text

Medicine, Cardiology, Pharmacology +17

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis

Kenji Chiba, Hirotoshi Kataoka, Noriyasu Seki et al. · International Immunopharmacology · 2010 · 67 citations

Life Sciences, Neurology, Neuroscience +16

Removal of Sphingosine 1-Phosphate Receptor-3 (S1P₃) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P₁ Agonists with Reduced Effect on Heart Rate

Maiko Hamada, Mitsuharu Nakamura, Masatoshi Kiuchi et al. · Journal of Medicinal Chemistry · 2010 · 41 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11