A novel ubiquitin ligase is deficient in Fanconi anemia

Amom Ruhikanta Meetei, Johan P. de Winter, Annette L. Medhurst, +10

Nature Genetics

Novel Ubiquitin LigaseGeneticsHematologyMolecular BiologyMolecular Genetics +2

A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

Amom Ruhikanta Meetei, Salvatore Sechi, Michael Wallisch, +5

Molecular and Cellular Biology

ChromatinGenome InstabilityProtein FunctionCell DivisionMedicine +10

Termination of Mammalian rDNA Replication: Polar Arrest of Replication Fork Movement by Transcription Termination Factor TTF-I

Josef‐Karl Gerber, Eric Gögel, Christian Berger, +4

Cell

ChromatinTranscriptional RegulationChromatin StructureReplication Fork MovementGenetics +10

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, +10

Blood

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Christina U. Lorentz, Norah G. Verbout, Michael Wallisch, +9

Arteriosclerosis Thrombosis and Vascular Biology

ImmunohematologyImmunologyPharmacotherapyFxi ActivationImmunotherapy +18

Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks

Alexandra Sobeck, Stacie Stone, Vincenzo Costanzo, +13

Molecular and Cellular Biology

ChromatinGenome InstabilityFanconi AnemiaCell DivisionChromatin Remodeling +13

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

Rachel A. Rigg, Joseph E. Aslan, Laura D. Healy, +7

American Journal of Physiology-Cell Physiology

Tyrosine KinaseImmunologyBlood CellPlatelet PathobiologyOral Administration +23

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Michael Wallisch, Christina U. Lorentz, Hari Hara Sudhan Lakshmanan, +8

Research and Practice in Thrombosis and Haemostasis

FANCD2 protein is expressed in proliferating cells of human tissues that are cancer‐prone in Fanconi anaemia

Michael Hölzel, P. J. van Diest, Patrick Bier, +4

The Journal of Pathology

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Erica Sparkenbaugh, Michael W. Henderson, Megan D Miller-Awe, +21

Blood