Xiaoxi Fan

Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage

Bozhi Ye, Xiaowen Shi, Jianjiang Xu et al. · Translational research · 2022 · 64 citations

Cardiovascular Toxicity, Cardiomyopathy, Heart Failure +10

Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF-κB Axis

Xiaoxi Fan, Jibo Han, Lingfeng Zhong et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2024 · 51 citations · Full text

GSDMD (Gasdermin D) Mediates Pathological Cardiac Hypertrophy and Generates a Feed-Forward Amplification Cascade via Mitochondria-STING (Stimulator of Interferon Genes) Axis

Jibo Han, Shanshan Dai, Lingfeng Zhong et al. · Hypertension · 2022 · 48 citations · Full text

Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation

Lingfeng Zhong, Jibo Han, Xiaoxi Fan et al. · Basic Research in Cardiology · 2023 · 39 citations

Cardiomyopathy, Heart Failure, Molecular Physiology +13

Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD

Shanshan Dai, Yunxuan Chen, Xiaoxi Fan et al. · Phytomedicine · 2023 · 30 citations

Inflammation, Molecular Pharmacology, Doxorubicin-induced Cardiotoxicity +15