Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Richard Possemato, Kevin M. Marks, Yoav D. Shaul, +24

Nature

Tumor BiologyBreast OncologyMedicineSerine Synthesis PathwayMolecular Biology +7

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen, +6

Developmental Cell

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationMtorc Components Raptor +6

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

Gizem Karsli-Uzunbas, Jessie Yanxiang Guo, Sandy M. Price, +8

Cancer Discovery

Tumours with PI3K activation are resistant to dietary restriction

Nada Y. Kalaany, David M. Sabatini

Nature

OncologyChemoprevention StrategyPi3k ActivationOncogenic AgentMedicine +5

LXRs regulate the balance between fat storage and oxidation

Nada Y. Kalaany, Karine Gauthier, Ann Marie Zavacki, +7

Cell Metabolism

Molecular PhysiologyBiochemistryPhysiologyMetabolic RegulationMetabolic State +5

Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer

Min-Sik Lee, Courtney Dennis, Insia Naqvi, +16

Nature

Pancreatic CancerOrnithine AminotransferaseOncogenic AgentMedicinePharmacology +1

Starved epithelial cells uptake extracellular matrix for survival

Taru Muranen, Marcin Iwanicki, Natasha Curry, +7

Nature Communications

Critical role for arginase 2 in obesity-associated pancreatic cancer

Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, +11

Nature Communications

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation

Marwan El‐Sabban, Agnel Sfeir, Myriam H. Daher, +3

Journal of Cell Science

ImmunologyCell CultureGap JunctionCellular PhysiologyMammary Gland Development +15

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, +16

Proceedings of the National Academy of Sciences