Increased Cellular Free Cholesterol in Macrophage-specific Abca1 Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

Xuewei Zhu, Ji‐Young Lee, Jenelle M. Timmins, +9

Journal of Biological Chemistry

Abca1 ProteinInnate Immune SystemImmunologyCellular Free CholesterolMacrophage-specific Abca1 Knock-out +14

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

Xuewei Zhu, J.S. Owen, Martha D. Wilson, +6

Journal of Lipid Research

Innate Immune SystemImmunologyInnate ImmunityMacrophage Abca1Myd88-dependent Toll-like Receptor +20

Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice

Marit Westerterp, Andrew Murphy, Mi Wang, +13

Circulation Research

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Ayaka Ito, Cynthia Hong, Xin Rong, +6

eLife

Inflammatory Lung DiseaseInnate Immune SystemImmune RegulationImmunologyInnate Immunity +22

A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

Shokouh Ahmadi, Shaohua Wang, Ravinder Nagpal, +8

JCI Insight

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice

Shaohua Wang, Shokouh Ahmadi, Ravinder Nagpal, +9

GeroScience

InflammationProbioticLipoteichoic AcidDysbiosisBiochemistry +10

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

Yun‐Hee Youm, Thirumala‐Devi Kanneganti, Bolormaa Vandanmagsar, +8

Cell Reports

Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis

J. Mark Brown, Soonkyu Chung, Janet K. Sawyer, +13

Circulation

Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers

Mary G. Sorci‐Thomas, J.S. Owen, Brian Fulp, +8

Journal of Lipid Research

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

Lulu Shen, Yan Yang, Tiantong Ou, +9

Journal of Lipid Research