Perfusion seed cultures improve biopharmaceutical fed‐batch production capacity and product quality

William C. Yang, Jiuyi Lü, Chris Kwiatkowski, +4

Biotechnology Progress

EngineeringCell CultureNutraceutical ProductionBiomedical EngineeringBioprocess Engineering +17

Quick generation of <scp>R</scp> aman spectroscopy based in‐process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Brandon Berry, Terrence M. Dobrowsky, Rebecca C. Timson, +3

Biotechnology Progress

Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity

William C. Yang, Daniel F. Minkler, Rashmi Kshirsagar, +2

Journal of Biotechnology

Additional Volumetric CapacityBiomanufacturingEngineeringProduction TechnologyIndustrial Engineering +11

Characterization of trisulfide modification in antibodies

Sheng Gu, Dingyi Wen, Paul H. Weinreb, +8

Analytical Biochemistry

Trisulfide ModificationBioanalysisImmunologyAntibody ScreeningImmunochemistry +3

Addition of Valproic Acid to CHO Cell Fed-Batch Cultures Improves Monoclonal Antibody Titers

William C. Yang, Jiuyi Lü, Ngan B. Nguyen, +5

Molecular Biotechnology

Valproic AcidMedicineImmunologyCell CultureAntibody Engineering +4

Advanced process monitoring and feedback control to enhance cell culture process production and robustness

An Zhang, Valerie Liu Tsang, Brandon Moore, +4

Biotechnology and Bioengineering

EngineeringProcess DevelopmentCell CultureGlucose FeedFeed Strategy +21

Application of high‐throughput mini‐bioreactor system for systematic scale‐down modeling, process characterization, and control strategy development

Vijay Manikandan Janakiraman, Chris Kwiatkowski, Rashmi Kshirsagar, +2

Biotechnology Progress

EngineeringBioreactor TechnologyProcess DevelopmentHigh‐throughput Mini‐bioreactor SystemSystematic Scale‐down Modeling +16

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed‐batch cell culture

Rashmi Kshirsagar, Kyle McElearney, Alan Gilbert, +2

Biotechnology and Bioengineering

Immunocytochemical TechniqueTrisulfide ModificationImmunologyGlycobiologyCell Culture +22

Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess

Amr Ali, Ravali Raju, Rashmi Kshirsagar, +4

Biotechnology Journal

EngineeringLipid PeroxidationImmunologyCell DeathOxidative Stress +21

Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein

Justin T. McCue, Rashmi Kshirsagar, Keith Selvitelli, +8

Biologicals