Paolo Mellini

Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells

Dante Rotili, Domenico Tarantino, Angela Nebbioso et al. · Journal of Medicinal Chemistry · 2012 · 97 citations · Full text

Oncology, Chemoprevention Strategy, Phenylpropylthio Analogue 4B +14

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

Sérgio Valente, Paolo Mellini, Francesco Spallotta et al. · Journal of Medicinal Chemistry · 2015 · 78 citations

Chemoprevention Strategy, Molecular Biology, Cancer Biology +18

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD⁺-binding site

Paolo Mellini, Yukihiro Itoh, Hiroki Tsumoto et al. · Chemical Science · 2017 · 69 citations · Full text

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

M.M. Erburu, I. Muñoz-Cobo, Teresa Diaz-Perdigón et al. · Neuropharmacology · 2017 · 63 citations

Psychoactive Drug, Psychiatry, Prefrontal Cortex +14

Studying SIRT6 regulation using H3K56 based substrate and small molecules

Piia Kokkonen, Minna Rahnasto‐Rilla, Paolo Mellini et al. · European Journal of Pharmaceutical Sciences · 2014 · 55 citations

Chemical Biology, Signal Transduction, Biochemistry +10