An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Marc R. Mansour, Brian J. Abraham, Lars Anders, +12

Science

EngineeringMixed-phenotype Acute LeukemiaGeneticsMolecular BiologyEpigenetics +16

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, +13

Nature Genetics

Transcriptional RegulationSystems BiologyGliomaMycn-amplified NeuroblastomaGene Regulatory Network +5

<i>MYC</i> Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

Mark W. Zimmerman, Yu Liu, Shuning He, +12

Cancer Discovery

Recurrent Focal Copy-Number Changes and Loss of Heterozygosity Implicate Two Noncoding RNAs and One Tumor Suppressor Gene at Chromosome 3q13.31 in Osteosarcoma

Ivan Pašić, Adam Shlien, Adam D. Durbin, +5

Cancer Research

Osteosarcoma PatientsChromosome 3Q13.31MedicineGeneticsTumor Suppressor Gene +13

A first-generation pediatric cancer dependency map

Neekesh V. Dharia, Guillaume Kugener, Lillian M. Guenther, +23

Nature Genetics

MedicinePediatricsCancer RegistrationPediatric OncologyOncology +2

EP300 Selectively Controls the Enhancer Landscape of <i>MYCN</i> -Amplified Neuroblastoma

Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, +26

Cancer Discovery

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

Lu Wang, Tze King Tan, Adam D. Durbin, +12

Nature Communications

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

Hui Shi, Ting Tao, Brian J. Abraham, +4

Science Advances

RETRACTED: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

Ken Morita, Shuning He, Radosław P. Nowak, +9

Cell

Signal TransductionSignaling PathwayMedicineProtein Phosphatase 2AAllosteric Activators +7

The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, +19

Cell Reports