Darren M. Hutt

Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis

Xiaodong Wang, John D. Venable, Paul LaPointe et al. · Cell · 2006 · 595 citations · Full text

Fibrosis, Systems Biology, Pathology +3

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Darren M. Hutt, David Herman, Ana P. C. Rodrigues et al. · Nature Chemical Biology · 2009 · 250 citations · Full text

Chromatin, Fibrosis, Medicine +8

Small-molecule proteostasis regulators for protein conformational diseases

Barbara Calamini, Maria Catarina Silva, Franck Madoux et al. · Nature Chemical Biology · 2011 · 224 citations

Protein Function, Protein Folding, Natural Sciences +7

The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition

Darren M. Hutt, Daniela Roth, Hélène Vignaud et al. · PLoS ONE · 2014 · 104 citations · Full text

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

Daniela Roth, Darren M. Hutt, Jiansong Tong et al. · PLoS Biology · 2014 · 93 citations · Full text