Isabelle Vergely

Functionalized <i>N</i>‐aryl azetidinones as novel mechanism‐based inhibitors of neutrophil elastase

Michel Wakselman, Roger Joyeau, Randa Kobaiter et al. · FEBS Letters · 1991 · 33 citations · Full text

Medicinal Chemistry, Biosynthesis, Functionalized N-aryl Azetidinone +15

Inhibition of human leukocyte elastase by functionalized N-aryl azetidin-2-ones: substituent effects at C-3 and benzylic positions

Isabelle Vergely, Nicole Boggetto, V. I. Okochi et al. · European Journal of Medicinal Chemistry · 1995 · 30 citations

Inflammation, Medicinal Chemistry, Biochemistry +12

Interaction of human leukocyte elastase with a N-aryl azetidinone suicide substrate: Conformational analyses based on the mechanism of action of serine proteinases

Isabelle Vergely, Philippe Laugâa, M. Reboud-Ravaux · Journal of Molecular Graphics · 1996 · 23 citations

Protein Function, Cellular Enzymology, Biochemistry +11

Inhibition of human leukocyte elastase by functionalized N-aryl-3,3-dihalogenoazetidin-2-ones. Stereospecific synthesis and chiral recognition of dissymmetrically C3-substituted β-lactams

C. Doucet, Isabelle Vergely, Michèle Reboud‐Ravaux et al. · Tetrahedron Asymmetry · 1997 · 17 citations

Molecular Pharmacology, Medicinal Chemistry, Bioorganic Chemistry +13

Synthesis of N-glyoxylyl peptides and their in vitro evaluation as HIV-1 protease inhibitors

Driss Qasmi, Eve de Rosny, Loïc René et al. · Bioorganic & Medicinal Chemistry · 1997 · 14 citations

Medicinal Chemistry, Biochemistry, Medicine +11