Mark I. James

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

Mark I. James, Chinenye Iwuji, Glen R.B. Irving et al. · Cancer Letters · 2015 · 179 citations · Full text

Chemoprevention Strategy, Medicine, Cancer Stem Cell +13

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

Hong Cai, Edwina N. Scott, Abeer Othman A. Kholghi et al. · Science Translational Medicine · 2015 · 175 citations · Full text

Chemoprevention Strategy, Oxidative Stress, Oncology +17

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Bram Herpers, Berina Eppink, Mark I. James et al. · Nature Cancer · 2022 · 142 citations · Full text

Medicine, Immunology, Tumor Immunity +8

Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

Vicenç Ruiz de Porras, Sara Bystrup, Anna Martínez‐Cardús et al. · Scientific Reports · 2016 · 131 citations · Full text

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells

Aida Sarmiento-Castro, Eva Caamaño‐Gutiérrez, Andrew H. Sims et al. · Stem Cell Reports · 2020 · 33 citations · Full text