Akihisa Okamoto

Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka et al. · PLoS ONE · 2018 · 78 citations · Full text

Mitophagy, Mitochondrial Dysfunction, Lipid Peroxidation +21

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka et al. · Scientific Reports · 2017 · 57 citations · Full text

The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

Akihisa Okamoto, Masahiro Tanaka, Chisato Sumi et al. · BMC Anesthesiology · 2016 · 48 citations · Full text

Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity

Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka et al. · Scientific Reports · 2018 · 37 citations · Full text

Propofol-induced Cell Death, Cell Death, Cell Death Mechanisms +20

Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock

Nobuyuki Hamano, Kenichiro Nishi, Aki Onose et al. · Journal of Intensive Care · 2013 · 19 citations · Full text