CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Jiehui Deng, Eric S. Wang, Russell W. Jenkins, +43

Cancer Discovery

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Shohei Koyama, Esra A. Akbay, Yvonne Y. Li, +30

Cancer Research

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert, +10

Nature

Suppressive FunctionSignal TransductionMitochondrial FunctionT-regulatory CellImmunology +6

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

Camilla L. Christensen, Nicholas Kwiatkowski, Brian J. Abraham, +23

Cancer Cell

MedicineImmune Checkpoint InhibitorCancer BiologyAnti-cancer AgentCovalent Cdk7 Inhibitor +4

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

Chen Zhao, Katherine A. Cheng, Zandra E. Walton, +40

Nature

OncologyOncogenic AgentMedicineImmunologyTherapeutic Response +7

Mitochondrial ubiquinol oxidation is necessary for tumour growth

Inmaculada Martínez‐Reyes, Luzivette Robles Cardona, Hyewon Kong, +11

Nature

Mitochondrial BiogenesisBiochemistryMitochondrial FunctionMitochondrial DynamicMitochondrial Ubiquinol Oxidation +4

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Qingsong Liu, Chunxiao Xu, Sivapriya Kirubakaran, +23

Cancer Research

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis

Lauren Diebold, Hyea Jin Gil, Peng Gao, +3

Nature Metabolism

Developmental BiologyAngiogenesisMitochondrial FunctionVascular BiologyMedicine +5

A scalable platform to identify fungal secondary metabolites and their gene clusters

Kenneth D. Clevenger, Jin Woo Bok, Rosa Ye, +14

Nature Chemical Biology

BiologyFungal DiversitySecondary MetabolismBiosynthesisEngineering +10

A CRISPR screen identifies a pathway required for paraquat-induced cell death

Colleen R. Reczek, Kıvanç Birsoy, Hyewon Kong, +4

Nature Chemical Biology

GeneticsApoptosisCell DeathGenetic EngineeringParaquat-induced Cell Death +7