Noriko Joto

DX-8951F, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant

Noriko Joto, Mineko Ishii, Megumi Minami et al. · International Journal of Cancer · 1997 · 72 citations · Full text

Medicine, Oncology, Pharmacology +15

Antitumor effect of DT-5461a, a synthetic low-toxicity lipid a analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation

Toshihiko Akimoto, Eiji Kumazawa, Takeshi Jimbo et al. · International Journal of Immunopharmacology · 1994 · 12 citations

Life Sciences, Immunology, Oncology +13

DT-5461a, an antitumor synthetic lipid a analog, causes selective blood flow reduction in tumor tissue.

T. Akimoto, Eiji Kumazawa, Takahiro Jimbo et al. · PubMed · 1995 · 11 citations

Medicine, Oncology, Pharmacology +13

Intratumoral Production of Tumor Necrosis Factor Augmented by Endogenous Interferons Results in Potent Antitumor Effects of DT-5461, a Synthetic Lipid A Analog

Eiji Kumazawa, Toshihiko Akimoto, Yasuo Kita et al. · Journal of Immunotherapy · 1995 · 10 citations

Medicine, Oncology, Pharmacology +17

Production of tumor necrosis factor induced by synthetic low-toxicity lipid a analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase—MAP kinase signaling pathway in murine macrophages

Noriko Joto, Toshihiko Akimoto, Kazuhiko Someya et al. · Cellular Immunology · 1995 · 10 citations

Life Sciences, Biochemistry, Immunology +15