J. B. HARBRIDGE

Clavulanic acid and its derivatives. Structure elucidation of clavulanic acid and the preparation of dihydroclavulanic acid, isoclavulanic acid, esters and related oxidation products

A. G. BROWN, David F. Corbett, Jennifer Goodacre et al. · Journal of the Chemical Society Perkin Transactions 1 · 1984 · 50 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +9

A novel and stereocontrolled synthesis of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid, a potent broad spectrum β-lactamase inhibitor

Neal F. Osborne, N. J. P. BROOM, Steven Coulton et al. · Journal of the Chemical Society Chemical Communications · 1989 · 22 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6

Synthesis of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid, a potent broad spectrum β-lactamase inhibitor, from 6-aminopenicillanic acid

Neal F. Osborne, Richard J. Atkins, N. J. P. BROOM et al. · Journal of the Chemical Society Perkin Transactions 1 · 1994 · 16 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Wittig reactions with β-lactam carbonyl functions. The effect of C-7 substitution on the chemistry of penicillins and clavulanic acid derivatives

Martin L. Gilpin, J. B. HARBRIDGE, T. Trefor Howarth · Journal of the Chemical Society Perkin Transactions 1 · 1987 · 14 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

Wittig reactions with β-lactam carbonyls: a convenient means of protection. X-Ray crystal structure of p-nitrobenzyl-(2R,5R)-Z-7-methoxycarbonylmethylene-Z-3-(β-phthalimidoethylidene)-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

Martin L. Gilpin, J. B. HARBRIDGE, T. Trefor Howarth et al. · Journal of the Chemical Society Chemical Communications · 1981 · 13 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10