Merrill Ayres

Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper

Zhulun Wang, Jinsong Liu, Athena Sudom et al. · Structure · 2006 · 145 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)

Xiaoshan Min, Daniela Ungureanu, Sarah Sollid Maxwell et al. · Journal of Biological Chemistry · 2015 · 103 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3

Zhihong Li, Xianghong Wang, John Eksterowicz et al. · Journal of Medicinal Chemistry · 2014 · 72 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures

Kexue Li, Lawrence R. McGee, Ben Fisher et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +17

The Human <i>Pim-1</i> Gene Is Selectively Transcribed in Different Hemato-Lymphoid Cell Lines in Spite of a G+C-Rich Housekeeping Promoter

T C Meeker, Jonathan E. Loeb, Merrill Ayres et al. · Molecular and Cellular Biology · 1990 · 62 citations · Full text

Life Sciences, Genetics, Molecular Biology +9