Marc Therrien

A dimerization-dependent mechanism drives RAF catalytic activation

Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois et al. · Nature · 2009 · 488 citations

Catalysis, Molecular Catalysis, Biochemistry +1

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

Thomas Lamonerie, Jacques Tremblay, Christian Lanctôt et al. · Genes & Development · 1996 · 421 citations · Full text

Pituitary Cells, Genetics, Pituitary Development +17

KSR, a novel protein kinase required for RAS signal transduction

Marc Therrien, Henry C. Chang, Noah M. Solomon et al. · Cell · 1995 · 340 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +10

Inhibition of RAS function through targeting an allosteric regulatory site

Russell Spencer-Smith, Akiko Koide, Yong Zhou et al. · Nature Chemical Biology · 2016 · 292 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Regulation +8

KSR modulates signal propagation within the MAPK cascade.

Marc Therrien, Neil R. Michaud, Gerald M. Rubin et al. · Genes & Development · 1996 · 263 citations · Full text

Activated Ras, Engineering, Mapk Cascade +16