A dimerization-dependent mechanism drives RAF catalytic activation

Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois, +2

Nature

CatalysisMolecular CatalysisBiochemistryCatalyst Activation

Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

Thomas Lamonerie, Jacques Tremblay, Christian Lanctôt, +3

Genes & Development

Pituitary CellsGeneticsPituitary DevelopmentPituitary FormationTranscriptional Regulation +15

KSR, a novel protein kinase required for RAS signal transduction

Marc Therrien, Henry C. Chang, Noah M. Solomon, +3

Cell

Signal TransductionSignaling PathwayCell RegulationRas Signal TransductionNatural Sciences +8

Inhibition of RAS function through targeting an allosteric regulatory site

Russell Spencer-Smith, Akiko Koide, Yong Zhou, +20

Nature Chemical Biology

Signal TransductionSignaling PathwayMolecular RegulationG Protein-coupled ReceptorMechanism Of Action +6

KSR modulates signal propagation within the MAPK cascade.

Marc Therrien, Neil R. Michaud, Gerald M. Rubin, +1

Genes & Development

Activated RasEngineeringMapk CascadeCellular PhysiologySignaling Pathway +14

A Screen for Genes That Function Downstream of Ras1 During Drosophila Eye Development

Felix Karim, Henry C. Chang, Marc Therrien, +3

Genetics

Identification of Constitutive and Ras-Inducible Phosphorylation Sites of KSR: Implications for 14-3-3 Binding, Mitogen-Activated Protein Kinase Binding, and KSR Overexpression

Angela Cacace, Neil R. Michaud, Marc Therrien, +4

Molecular and Cellular Biology

14-3-3 BindingSystems BiologySignal TransductionDrosophila EyeSignaling Pathway +12

KSR is a scaffold required for activation of the ERK/MAPK module

François Roy, Gino Laberge, Mélanie Douziech, +2

Genes & Development

Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O

Nazar Mashtalir, Salima Daou, Haithem Barbour, +6

Molecular Cell

Signaling PathwayCell RegulationMedicineCytoplasmic Sequestration MediatedTumor Suppressor Bap1 +6

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

Hugo Lavoie, Neroshan Thevakumaran, Gwenaëlle Gavory, +8

Nature Chemical Biology

Drug TargetSignal TransductionMedicineReceptor Tyrosine KinaseRational Drug Design +4