E B Gralla

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

Darci J. Kane, Theodore A. Sarafian, Rein Anton et al. · Science · 1993 · 1.7K citations

Life Sciences, Cell Biology, Neuroscience +17

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

Shahrooz Rabizadeh, E B Gralla, David Borchelt et al. · Proceedings of the National Academy of Sciences · 1995 · 335 citations

Life Sciences, Molecular Biology, Neuroscience +17

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

Dindial Ramotar, S C Popoff, E B Gralla et al. · Molecular and Cellular Biology · 1991 · 208 citations

Life Sciences, Genetics, Molecular Biology +16

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

E B Gralla, Dennis J. Thiele, Philippe Silar et al. · Proceedings of the National Academy of Sciences · 1991 · 200 citations

Life Sciences, Genetics, Molecular Biology +15

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.

Thomas J. Lyons, H. Liu, Jun Goto et al. · Proceedings of the National Academy of Sciences · 1996 · 183 citations

Life Sciences, Biochemistry, Molecular Biology +14