Tomoya Kotake

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo et al. · Journal of the American Chemical Society · 2023 · 132 citations

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara et al. · Journal of the American Chemical Society · 2023 · 86 citations

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

Tomoya Kotake, Yoshio Hayashi, Yoshie Mukai et al. · Tetrahedron · 2005 · 35 citations

Engineering, Efficient Chiral Auxiliary, Organic Chemistry +6

A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: synthesis and application in solid-phase asymmetric alkylation reactions

Tomoya Kotake, Yoshio Hayashi, Yoshie Mukai et al. · Tetrahedron Letters · 2004 · 26 citations

Enantioselective Synthesis, Engineering, Organic Chemistry +7

Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist

Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki et al. · Journal of Medicinal Chemistry · 2020 · 26 citations · Full text