Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity

Patrick Dorr, Mike Westby, Susan Dobbs, +13

Antimicrobial Agents and Chemotherapy

Standard DeviationsImmunologyPharmacotherapyChemokine Receptor Ccr5Antiviral Drug +17

Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig

William B. Johnson, Sidath Katugampola, Sarah Able, +2

Life Sciences

Cardiac MuscleCardiomyopathyHeart FailureMolecular PhysiologyCgmp Phosphodiesterases +9

Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of eletriptan binding at human 5-HT1B and 5-HT1D receptors

Carolyn Napier, Michael Stewart, Heather L. Melrose, +3

European Journal of Pharmacology

Signal TransductionBiochemistryFunctional SelectivityMedicinePhysiology +6

Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc

David A. Price, Duncan Armour, Marcel de Groot, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyCcr5 Antagonist MaravirocMedicineHerg AffinityImmunology +3

Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M3-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland

Carl P. Nelson, Paul Gupta, Carolyn Napier, +2

Journal of Pharmacology and Experimental Therapeutics

Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human

Carolyn Napier, Harriet Sale, Michael Mosley, +4

Biochemical Pharmacology

Chemokine BiologyMolecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicine +9

Characterisation of the contractile activity of eletriptan at the canine vascular 5-HT1B receptor

Paul Gupta, Jon Scatchard, Carolyn Napier, +2

European Journal of Pharmacology

Signal TransductionMolecular PhysiologyFunctional SelectivityMedicinePhysiology +6

Overcoming hERG Affinity in the Discovery of Maraviroc; A CCR5 Antagonist for the Treatment of HIV

David A. Price, Duncan Armour, Marcel de Groot, +5

Current Topics in Medicinal Chemistry

ImmunologyHerg LiabilitiesLead IdentificationPharmacotherapyAntiviral Drug +16

Design and synthesis of a fluorescent muscarinic antagonist

Lyn H. Jones, Amy Randall, Carolyn Napier, +3

Bioorganic & Medicinal Chemistry Letters

MedicineMechanism Of ActionNeuropharmacologyPharmacotherapyPharmacology +2

Estimation of binding rate constants using a simultaneous mixed‐effects method: application to monoamine transporter reuptake inhibitor reboxetine

Neil Benson, Nelleke Snelder, Bart A. Ploeger, +5

British Journal of Pharmacology