Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity

Patrick Dorr, Mike Westby, Susan Dobbs, +13

Antimicrobial Agents and Chemotherapy

Standard DeviationsImmunologyPharmacotherapyChemokine Receptor Ccr5Antiviral Drug +17

Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry

Mike Westby, Caroline Smith‐Burchnell, Julie Mori, +6

Journal of Virology

Phenotypic Susceptibility AssaysImmunologyCcr5 AntagonistPharmacotherapyViral Strains Resistant +14

Novel Small-Molecule Inhibitors of RNA Polymerase III

Liping Wu, Jing Pan, Vala Thoroddsen, +14

Eukaryotic Cell

Cyanide oxygenase and cyanase activities of<i>Pseudomonas fluorescens</i>NCIMB 11764

Patrick Dorr, Christopher J. Knowles

FEMS Microbiology Letters

Oxygenase ActivityNcimb 11764EngineeringBiochemistryCyanide Oxygenase +11

An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of <i>N</i>-{(1<i>S</i>)-1-(3-Fluorophenyl)-3-[(3-<i>endo</i>)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1<i>H</i>-imidazo[4,5-<i>c</i>]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

Paul A. Stupple, David V. Batchelor, Martin Corless, +17

Journal of Medicinal Chemistry

Medicinal ChemistryMaraviroc 1Imidazopiperidine SeriesMedicineImmunology +13

Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: Effects of viral diversity, target cell and receptor density

Samantha J. Willey, Paul J. Peters, Wendy Sullivan, +3

Antiviral Research

Ccr5-mediated InfectionViral DiversityMedicineHuman RetrovirusImmunology +10

CCR5 inhibitors in HIV-1 therapy

Patrick Dorr, Manos Perros

Expert Opinion on Drug Discovery

Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences

Justin E. Ideozu, Mengzhen Liu, Bridget Riley‐Gillis, +9

Genome Medicine

Chapter 2 CCR5 Pharmacology Methodologies and Associated Applications

Roy Mansfield, Sarah Able, Paul Griffin, +13

Methods in enzymology on CD-ROM/Methods in enzymology

Systems PharmacologyMolecular PharmacologyTranslational PharmacologyChapter 2Pharmacology +6

Real‐world safety and effectiveness of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin in hepatitis C virus genotype 1‐ and 4‐infected patients with diverse comorbidities and comedications: A pooled analysis of post‐marketing observational studies from 13 countries

Péter Ferenci, Stefan Bourgeois, Peter Buggisch, +11

Journal of Viral Hepatitis