Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Bertram Bengsch, Takuya Ohtani, Omar Khan, +12

Immunity

Epigenomic-guided Mass CytometryCancer ImmunosurveillanceAutoimmune DiseaseT-regulatory CellImmunology +10

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

Mariko Takahashi-Tezuka, Yuichi Yoshida, Toshiyuki Fukada, +6

Molecular and Cellular Biology

Dissection of Signaling Cascades through gp130 In Vivo

Takuya Ohtani, Katsuhiko Ishihara, Toru Atsumi, +11

Immunity

Signal TransductionSignaling PathwayMolecular PathwayG Protein-coupled ReceptorMedicine +4

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

Keigo Nishida, Yuichi Yoshida, Motoyuki Itoh, +8

Blood

A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis

Toru Atsumi, Katsuhiko Ishihara, Daisuke Kamimura, +8

The Journal of Experimental Medicine

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

Yumi Yashiro–Ohtani, Yiping He, Takuya Ohtani, +9

Genes & Development

T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma

Maryam Barsch, Henrike Salié, Alexandra Emilia Schlaak, +30

Journal of Hepatology

T-cell ExhaustionHepatologyResidency DynamicsMedicineLiver Physiology +9

Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Katelyn T. Byrne, Courtney B. Betts, Rosemarie Mick, +26

Clinical Cancer Research

Tissue-Specific Autoregulation of the <i>stat3</i> Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells

Masahiro Narimatsu, H. Maeda, Shousaku Itoh, +12

Molecular and Cellular Biology

Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

Yan Xiao, Yasuhiro Nagai, Guoping Deng, +9

Cell Reports

T-regulatory CellImmune RegulationImmunologyMolecular BiologyCell Death +20