Jie Yang

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu et al. · Science Immunology · 2018 · 561 citations · Full text

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

Zhonghua Liu, Chuanping Wang, Jie Yang et al. · Immunity · 2019 · 256 citations · Full text

Full-length Murine, Proteinlipid Interaction, Biochemistry +4

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

Zhonghua Liu, Chuanping Wang, Jie Yang et al. · Immunity · 2020 · 201 citations · Full text

Proteinlipid Interaction, Distinct Interfaces, Protein Secretion +11

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

Jie Yang, Chuanping Wang, Rui Yang et al. · Proceedings of the National Academy of Sciences · 2018 · 174 citations · Full text

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

Xuerong Sun, Benyan Shi, Huiling Zheng et al. · Cell Death and Disease · 2018 · 92 citations · Full text