Jie Yang

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu et al. · Science Immunology · 2018 · 595 citations · Full text

Life Sciences, Immunology, Cell Signaling +1

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

Zhonghua Liu, Chuanping Wang, Jie Yang et al. · Immunity · 2019 · 265 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

Zhonghua Liu, Chuanping Wang, Jie Yang et al. · Immunity · 2020 · 213 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +8

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

Jie Yang, Chuanping Wang, Rui Yang et al. · Proceedings of the National Academy of Sciences · 2018 · 180 citations · Full text

Life Sciences, Cell Biology, Immunology +14

Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway

Xuerong Sun, Benyan Shi, Huiling Zheng et al. · Cell Death and Disease · 2018 · 93 citations · Full text

Medicine, Oncology, Pharmacology +14