Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

Bo Ding, Chengheng Lin, Qian Liu, +7

Journal of Neuroinflammation

TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, +10

Experimental Neurology

Signal TransductionMolecular NeuroscienceSynaptic SignalingMedicineApp/ps1 Transgenic Mice +10

The effects of perindopril on cognitive impairment induced by d-galactose and aluminum trichloride via inhibition of acetylcholinesterase activity and oxidative stress

Weina Yang, Hua Han, Xiaodan Hu, +2

Pharmacology Biochemistry and Behavior

Alzheimer's DiseaseAcetylcholinesterase ActivityMedicineDementiaNeuroprotection +4

The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons

Lili Shi, Weina Yang, Xinlin Chen, +6

Neurochemistry International

Neurodegenerative Diseasesβ-Amyloid ProteinPrimary Cortical NeuronsMedicineTanshinone Iia +6

Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice

Shanshan Zhao, Weina Yang, Hui Jin, +2

NeuroToxicology

Inhibits Oxidative StressMedicineStz-induced Sad MicePhysiologyMemory Impairments +6

TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro

Xiaoqian Peng, Hongsong Guo, Xiao Zhang, +7

Molecular Neurobiology

Neurodegenerative DiseasesMolecular NeuroscienceSignal TransductionSynaptic SignalingSignaling Pathway +12

Protective effects of perindopril on d-galactose and aluminum trichloride induced neurotoxicity via the apoptosis of mitochondria-mediated intrinsic pathway in the hippocampus of mice

Weina Yang, Lili Shi, Lianji Chen, +4

Brain Research Bulletin

Mitochondria-mediated Intrinsic PathwayBiochemistryAluminum TrichlorideMedicineApoptosis +12

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice

Yingying He, John Bosco Ruganzu, Chengheng Lin, +13

Neurochemistry International

Iia AmelioratesMedicineApoptosisCell DeathApp/ps1 Transgenic Mice +7

Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease

John Bosco Ruganzu, Xiaoqian Peng, Yingying He, +8

Molecular Immunology

ImmunologyTransgenic Mouse ModelSynaptic SignalingNeuroinflammationInflammation +15

Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice

Chang Liu, Youxuan Wu, Shuai Zha, +9

Brain Research

Memory DeficitsNeurophysiologyMedicineTanshinone IiaMemory +10