John Bosco Ruganzu

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

Bo Ding, Chengheng Lin, Qian Liu et al. · Journal of Neuroinflammation · 2020 · 186 citations · Full text

TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu et al. · Experimental Neurology · 2020 · 108 citations

Signal Transduction, Molecular Neuroscience, Synaptic Signaling +12

TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro

Xiaoqian Peng, Hongsong Guo, Xiao Zhang et al. · Molecular Neurobiology · 2023 · 56 citations

Neurodegenerative Diseases, Molecular Neuroscience, Signal Transduction +14

Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice

Yingying He, John Bosco Ruganzu, Chengheng Lin et al. · Neurochemistry International · 2019 · 53 citations

Iia Ameliorates, Medicine, Apoptosis +9

Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease

John Bosco Ruganzu, Xiaoqian Peng, Yingying He et al. · Molecular Immunology · 2021 · 49 citations

Immunology, Transgenic Mouse Model, Synaptic Signaling +17