De-pu Wang

Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold

De-pu Wang, Kai-li Liu, Xinyang Li et al. · European Journal of Medicinal Chemistry · 2020 · 73 citations · Full text

Angiogenesis, 1,2,3-Triazole Scaffold, Medicine +8

Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC

Xinyang Li, De-pu Wang, Guoqing Lu et al. · Journal of Advanced Research · 2020 · 19 citations · Full text

Novel 4,5-dihydrospiro[benzo[c]azepine-1,1′-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation

Shuai Li, Xinyang Li, Tingjian Zhang et al. · Bioorganic Chemistry · 2021 · 19 citations

Medicinal Chemistry, Biochemistry, Medicine +8

Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity

Xinyang Li, Tingjian Zhang, Mohamed Olounfeh Kamara et al. · Cell Death and Disease · 2019 · 18 citations · Full text

Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis

Xinyang Li, De-pu Wang, Shuai Li et al. · Bioorganic Chemistry · 2021 · 18 citations

Combinatorial Chemistry, Medicinal Chemistry, Benzamide Derivatives +10