Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

Xin Cui, Chao Ma, Varshini Vasudevaraja, +16

eLife

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

Aram S. Modrek, Danielle Golub, Themasap A. Khan, +30

Cell Reports

Epigenetic ChangeGeneticsCerebral OrganoidCell SpecializationGlioma +22

Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase–mutant Glioma

Marissa Spino, Sylvia C. Kurz, Luis Chiriboga, +23

Clinical Cancer Research

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

N. Sumru Bayın, Joshua D. Frenster, Rajeev Sen, +18

Oncotarget

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth

Joshua D. Frenster, J. Robert Kane, Jordan Rubenstein, +17

Oncogenesis

The H3K36me2 writer-reader dependency in H3K27M-DIPG

Jia-Ray Yu, Gary LeRoy, Devin Bready, +7

Science Advances

Histone ModificationsChromatinGliomaMedicineHistone H3k27m +12

Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

Joshua D. Frenster, Gabriele Stephan, Niklas Ravn-Boess, +9

Journal of Biological Chemistry

GPR133 Promotes Glioblastoma Growth in Hypoxia

Joshua D. Frenster, Julio Inocencio, Zhongye Xu, +5

Neurosurgery

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, +30

Cell Reports

Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes

Joshua D. Frenster, Michael Kader, Scott Kamen, +24

Neuro-Oncology Advances