Jim Leisten

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Brydon L. Bennett, Dennis T. Sasaki, Brion W. Murray et al. · Proceedings of the National Academy of Sciences · 2001 · 2.6K citations · Full text

Life Sciences, Immunology, Pharmacology +17

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Joshua D. Hansen, Matthew Correa, Mark A. Nagy et al. · Journal of Medicinal Chemistry · 2020 · 218 citations · Full text

Medicine, Oncology, Pharmacology +13

Discovery of (<i>S</i>)-<i>N</i>-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1<i>H</i>-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Hon‐Wah Man, Peter Schäfer, Lu Min Wong et al. · Journal of Medicinal Chemistry · 2009 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

An activin receptor <scp>II</scp>A ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin

Soraya Carrancio, Jennifer A. Markovics, Piu Wong et al. · British Journal of Haematology · 2014 · 121 citations · Full text

Life Sciences, Cell Biology, Hematology +15

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin et al. · Journal of Medicinal Chemistry · 2015 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14