Weixuan Yu

Direct inhibitors of InhA are active against <i>Mycobacterium tuberculosis</i>

Ujjini H. Manjunatha, Srinivasa P. S. Rao, Ravinder Reddy Kondreddi et al. · Science Translational Medicine · 2015 · 129 citations · Full text

A Structural and Energetic Model for the Slow-Onset Inhibition of the <i>Mycobacterium tuberculosis</i> Enoyl-ACP Reductase InhA

Huei-Jiun Li, Cheng‐Tsung Lai, Pan Pan et al. · ACS Chemical Biology · 2014 · 66 citations · Full text

Slow-onset Inhibition, Protein Assembly, Energetic Model +17

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

J. Schiebel, Andrew Chang, Sonam Shah et al. · Journal of Biological Chemistry · 2014 · 63 citations · Full text

Medicinal Chemistry, Antimicrobial Susceptibility, Biochemistry +12

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the <i>Staphylococcus aureus</i> FabI Enzyme–Product Complex

Andrew Chang, J. Schiebel, Weixuan Yu et al. · Biochemistry · 2013 · 60 citations · Full text

Drug Target, Chemical Biology, Rational Optimization +16

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

Lauren A. Spagnuolo, Sandra Eltschkner, Weixuan Yu et al. · Journal of the American Chemical Society · 2017 · 56 citations · Full text