BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

Artur Słupianek, Christoph Schmütte, Gregory Tombline, +6

Molecular Cell

Molecular PharmacologySignal TransductionMolecular RegulationMedicineCell Biology +1

Signal Transducer and Activator of  Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

Malgorzata Nieborowska-Skorska, Mariusz A. Wasik, Artur Słupianek, +4

The Journal of Experimental Medicine

Tyrosine KinaseImmunologyCell DeathBcr/abl Src HomologyMyeloid Neoplasia +14

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species–dependent DNA double-strand breaks

Michal O. Nowicki, Rafal Falinski, Mateusz Koptyra, +6

Blood

Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G₂/M Phase, and Protection from Apoptosis

Artur Słupianek, Grażyna Hoser, Ireneusz Majsterek, +4

Molecular and Cellular Biology

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571

Agata Klejman, Lori Rushen, Andrea Morrione, +2

Oncogene

Molecular PharmacologyMedicinePhosphatidylinositol-3 Kinase InhibitorsReceptor Tyrosine KinaseAnti-cancer Agent +2

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Kara Scheibner, +15

Blood

BCR/ABL Inhibits Mismatch Repair to Protect from Apoptosis and Induce Point Mutations

Tomasz Stokłosa, Tomasz Popławski, Mateusz Koptyra, +8

Cancer Research

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

Kimberly Cramer, Margaret Nieborowska-Skorska, Mateusz Koptyra, +5

Cancer Research

BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells

Artur Słupianek, Michal O. Nowicki, Mateusz Koptyra, +1

DNA repair

Hematological MalignancyChromatinGenome InstabilityDna DamageHematopoietic Cells +9

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells

Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, +29

Journal of Clinical Investigation

Mixed-phenotype Acute LeukemiaCell DeathLeukemia CellsTumor BiologyPersonalized Medicine Approach +16