Eva Caroff

4-((<i>R</i>)-2-{[6-((<i>S</i>)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y₁₂ Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel

Eva Caroff, Francis Hubler, Emmanuel A. Meyer et al. · Journal of Medicinal Chemistry · 2015 · 50 citations

Medicine, Medicinal Chemistry, Pharmacology +12

The isomerisation of (Z)-3-[²H₁]-phenylprop-2-enone as a measure of the rate of hydroperoxide addition in Weitz–Scheffer and Juliá–Colonna epoxidations

David R. Kelly, Eva Caroff, Robert W. Flood et al. · Chemical Communications · 2004 · 43 citations

Life Sciences, Biochemistry, Natural Product Biosynthesis +3

Structure and catalytic activity of some soluble polyethylene glycol–peptide conjugates

David R. Kelly, Tam T. T. Bui, Eva Caroff et al. · Tetrahedron Letters · 2004 · 30 citations

Life Sciences, Biochemistry, Chemistry +9

Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y12 antagonists for inhibition of platelet aggregation

Eva Caroff, Emmanuel A. Meyer, Alexander Treiber et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 30 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

The reversible P2Y₁₂antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat

Markus Rey, Markus Kramberg, Patrick Hess et al. · Pharmacology Research & Perspectives · 2017 · 29 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17