Catherine Higgins

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

Joanna Majkut, Miriam Sgobba, Caitriona Holohan et al. · Nature Communications · 2014 · 82 citations · Full text

Protein Function, Signal Transduction, Protein Assembly +13

A revised model of <scp>TRAIL</scp> ‐R2 <scp>DISC</scp> assembly explains how <scp>FLIP</scp> (L) can inhibit or promote apoptosis

Luke Humphreys, Jennifer Fox, Catherine Higgins et al. · EMBO Reports · 2020 · 55 citations · Full text

Mechanistic and anti-proliferative studies of two novel, biologically active bis-benzimidazoles

Angela Seaton, Catherine Higgins, John Mann et al. · European Journal of Cancer · 2003 · 45 citations

Combinatorial Chemistry, Biochemistry, Natural Sciences +8

TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

Zenobia D’Costa, Catherine Higgins, Chee Wee Ong et al. · Oncotarget · 2014 · 43 citations · Full text

cFLIPL acts as a suppressor of TRAIL- and Fas-initiated inflammation by inhibiting assembly of caspase-8/FADD/RIPK1 NF-κB-activating complexes

Pavel B. Davidovich, Catherine Higgins, Zaneta Najda et al. · Cell Reports · 2023 · 42 citations · Full text