Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors:  Safinamide and Coumarin Analogs

Claudia Binda, Jin Wang, Leonardo Pisani, +5

Journal of Medicinal Chemistry

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2<i>H</i>-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible, and Orally Active Monoamine Oxidase B Inhibitor

Leonardo Pisani, Giovanni Muncipinto, Teresa Fabiola Miscioscia, +9

Journal of Medicinal Chemistry

Structure-Based Design and Optimization of Multitarget-Directed 2<i>H</i>-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

Roberta Farina, Leonardo Pisani, Marco Catto, +11

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal ChemistryStructure-based Design +14

Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-α-Hydroxylase/C17−20 Lyase

Angela Stefanachi, Angelo D. Favia, Orazio Nicolotti, +6

Journal of Medicinal Chemistry

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

Leonardo Pisani, Roberta Farina, Marco Catto, +9

Journal of Medicinal Chemistry

Drug TargetHmao BNeurochemical BiomarkersPre-clinical PharmacologySystems Pharmacology +19

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

Marco Catto, Leonardo Pisani, Francesco Leonetti, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryCoumarin AlkylaminesNatural SciencesMedicine +6

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs

Lara Napolitano, Mariafrancesca Scalise, Maria Koyioni, +10

Biochemical Pharmacology

Medicinal ChemistryHuman Lat1Pharmaceutical ScienceMedicinePharmacological Agent +8

5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques

Leonardo Pisani, Hana Prokopcová, Jennifer M. Kremsner, +1

Journal of Combinatorial Chemistry

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer’s disease

Bruno Tasso, Marco Catto, Orazio Nicolotti, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)Alzheimer's DiseaseBiochemistryQuinolizidinyl Derivatives +9

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, +16

European Journal of Medicinal Chemistry

X-ray CrystallographyProtein AssemblyBiochemistryNanomolar Multifunctional LigandsNatural Sciences +8