Isak W. Tengesdal

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Carlo Marchetti, Benjamin J. Swartzwelter, Fabia Gamboni et al. · Proceedings of the National Academy of Sciences · 2018 · 559 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

Viola Klück, Tim Jansen, M. Janssen et al. · The Lancet Rheumatology · 2020 · 290 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Isak W. Tengesdal, Dinoop Ravindran Menon, Douglas G. Osborne et al. · Proceedings of the National Academy of Sciences · 2021 · 193 citations · Full text

Life Sciences, Immunology, Oncology +17

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti, Benjamin J. Swartzwelter, Marije I. Koenders et al. · Arthritis Research & Therapy · 2018 · 161 citations · Full text

Medicine, Immunology, Pharmacology +17

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers et al. · Frontiers in Immunology · 2021 · 126 citations · Full text

Life Sciences, Immunology, Oncology +17