Isak W. Tengesdal

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Carlo Marchetti, Benjamin J. Swartzwelter, Fabia Gamboni et al. · Proceedings of the National Academy of Sciences · 2018 · 520 citations · Full text

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

Viola Klück, Tim Jansen, M. Janssen et al. · The Lancet Rheumatology · 2020 · 257 citations · Full text

Anti-inflammatory, Gouty Arthritis, Pharmacology +8

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Isak W. Tengesdal, Dinoop Ravindran Menon, Douglas G. Osborne et al. · Proceedings of the National Academy of Sciences · 2021 · 183 citations · Full text

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti, Benjamin J. Swartzwelter, Marije I. Koenders et al. · Arthritis Research & Therapy · 2018 · 155 citations · Full text

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers et al. · Frontiers in Immunology · 2021 · 121 citations · Full text