Emma Rose Scaletti

Massively parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicity

Chase C. Suiter, Takaya Moriyama, Kenneth A. Matreyek et al. · Proceedings of the National Academy of Sciences · 2020 · 140 citations · Full text

Medicine, Genetics, Molecular Genetics +17

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina Gustafsson, Martin Henriksson et al. · Nature Cancer · 2022 · 105 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Discovery of AB680: A Potent and Selective Inhibitor of CD73

Kenneth V. Lawson, Jarosław Kalisiak, Erick A. Lindsey et al. · Journal of Medicinal Chemistry · 2020 · 92 citations · Full text

Medicine, Oncology, Pharmacology +15

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Maurice Michel, Carlos Benitéz‐Buelga, Patricia A. Calvo et al. · Science · 2022 · 75 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5′-nucleotidase (CD73) Inhibitors with Variable Binding Modes

Sanjay Bhattarai, Jan Pippel, Emma Rose Scaletti et al. · Journal of Medicinal Chemistry · 2020 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12