Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex

Alexei Vassilev, Zahide Özer, Christopher S. Navara, +2

Journal of Biological Chemistry

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

Fatih M. Uckun, Sanjive Qazi, Hong Ma, +2

Proceedings of the National Academy of Sciences

Syk Tyrosine KinaseImmunologyCell DeathImmunologic MechanismTumor Biology +16

Transcription Factor STAT5A Is a Substrate of Bruton's Tyrosine Kinase in B Cells

Sandeep Mahajan, Alexei Vassilev, Nancy Sun, +3

Journal of Biological Chemistry

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

Fatih M. Uckun, Hong Ma, Jian Zhang, +6

Proceedings of the National Academy of Sciences

Transcription Factor FunctionSerine PhosphorylationImmunologyMolecular BiologyCell Cycle +16

The other function of DNA photolyase: stimulation of excision repair of chemical damage to DNA

Zahide Özer, Joyce T. Reardon, David S. Hsu, +2

Biochemistry

Active Center Cleft Residues of Pokeweed Antiviral Protein Mediate Its High-Affinity Binding to the Ribosomal Protein L3

Francis Rajamohan, Zahide Özer, Mao Chen, +1

Biochemistry

Viral ReplicationProtein AssemblyMolecular BiologyViral Structural ProteinChemical Biology +14

Polo‐like‐kinase 1 (PLK1) as a molecular target to overcome SYK‐mediated resistance of B‐lineage acute lymphoblastic leukaemia cells to oxidative stress

Fatih M. Uckun, Zahide Özer, Sanjive Qazi, +2

British Journal of Haematology

Syk‐mediated ResistanceSyk Tyrosine KinaseApoptosisImmunologyCell Death +15

Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia

Fatih M. Uckun, Dorothea E. Myers, Sanjive Qazi, +4

Journal of Clinical Investigation

Hematological MalignancyCell TherapyMixed-phenotype Acute LeukemiaMalignant Blood DisorderApoptosis +12

Bruton's tyrosine kinase prevents activation of the anti‐apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B‐cells and B‐cell precursors exposed to oxidative stress

Fatih M. Uckun, Zahide Özer, Alexei Vassilev

British Journal of Haematology

Tyrosine KinaseApoptosisImmunologyCell DeathTumor Biology +16

CD22 Exon 12 deletion is a characteristic genetic defect of therapy‐refractory clones in paediatric acute lymphoblastic leukaemia

Hong Ma, Sanjive Qazi, Zahide Özer, +3

British Journal of Haematology

Mixed-phenotype Acute LeukemiaImmunologyPathologyTherapy‐refractory ClonesImmunotherapy +22