Iain Kilty

Cigarette smoke induces proinflammatory cytokine release by activation of NF-κB and posttranslational modifications of histone deacetylase in macrophages

Se‐Ran Yang, Asiya Seema Chida, Mark R. Bauter et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2006 · 488 citations

Inflammatory Lung Disease, Lung Inflammation, Immunology +17

Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF‐κB activation and proinflammatory cytokine release in alveolar epithelial cells

Fiona M. Moodie, John A. Marwick, Charlotte S. Anderson et al. · The FASEB Journal · 2004 · 325 citations

PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor

Hua Xu, Michael I. Jesson, Uthpala Seneviratne et al. · ACS Chemical Biology · 2019 · 152 citations

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

Kylie Belchamber, Richa Singh, Craig Batista et al. · European Respiratory Journal · 2019 · 131 citations · Full text