Role of duplicate genes in genetic robustness against null mutations

Zhenglong Gu, Lars M. Steinmetz, Xun Gu, +3

Nature

Genetic AnalysisAllelic VariantMedicineGeneticsEvolutionary Biology +9

Evolutionary Rate in the Protein Interaction Network

Hunter B. Fraser, Aaron E. Hirsh, Lars M. Steinmetz, +2

Science

BiologyProtein Interaction NetworkEngineeringInteractomicsNatural Sciences +12

Systematic screen for human disease genes in yeast

Lars M. Steinmetz, Curt Scharfe, Adam M. Deutschbauer, +8

Nature Genetics

Systematic ScreenGeneticsYeastGene CharacterizationDisease Gene Identification +2

The Role of Selection in the Evolution of Human Mitochondrial Genomes

Toomas Kivisild, Peidong Shen, Dennis P. Wall, +14

Genetics

Recurrent MutationGeneticsMolecular GeneticsGenomicsHuman Mitochondrial Genomes +18

The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein

Carsten M. Pusch, Christina Zeitz, Oliver Brandau, +11

Nature Genetics

Developmental AnomalyMendelian DisorderOphthalmologyGenetic DisorderGenetics +7

Integrative Analysis of the Mitochondrial Proteome in Yeast

Holger Prokisch, Curt Scharfe, David Camp, +17

PLoS Biology

GeneticsProteasomeMolecular BiologyGenomicsMitochondrial Biogenesis +14

Massively parallel discovery of human-specific substitutions that alter enhancer activity

Severin Uebbing, Jake Gockley, Steven K. Reilly, +6

Proceedings of the National Academy of Sciences

Mapping Gene Associations in Human Mitochondria using Clinical Disease Phenotypes

Curt Scharfe, Henry Horng‐Shing Lu, Jutta K. Neuenburg, +6

PLoS Computational Biology

GeneticsGenetic EpidemiologyMolecular GeneticsMitochondrial BiologyDisease Gene Identification +22

Proteome analysis of mitochondrial outer membrane from <b> <i>Neurospora crassa</i> </b>

Simone Schmitt, Holger Prokisch, Tilman Schlunck, +9

PROTEOMICS

A novel mutation in the thiamine responsive megaloblastic anaemia gene <i>SLC19A2</i> in a patient with deficiency of respiratory chain complex I

Curt Scharfe

Journal of Medical Genetics