Richard O’Laughlin

A programmable fate decision landscape underlies single-cell aging in yeast

Yang Li, Yanfei Jiang, Julie Paxman et al. · Science · 2020 · 136 citations · Full text

A patterned human neural tube model using microfluidic gradients

Xufeng Xue, Yung Su Kim, Isaac Ponce et al. · Nature · 2024 · 98 citations · Full text

Engineering, Neurophysiology, Computational Neuroscience +10

Multigenerational silencing dynamics control cell aging

Yang Li, Meng Jin, Richard O’Laughlin et al. · Proceedings of the National Academy of Sciences · 2017 · 79 citations · Full text

Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics

Meng Jin, Yang Li, Richard O’Laughlin et al. · Cell Systems · 2019 · 63 citations · Full text

Single-cell Phenotypic Dynamics, Aging, Longevity +9

Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis

Julie Paxman, Zhen Zhou, Richard O’Laughlin et al. · eLife · 2022 · 33 citations · Full text