A role for the apoptosis inhibitory factor AIM/Spα/Api6 in atherosclerosis development

Satoko Arai, John M. Shelton, Mingyi Chen, +8

Cell Metabolism

InflammationVascular DiseaseAtherosclerosis DevelopmentCardiovascular DiseaseAtherosclerosis +12

Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis

Kazuhiro Kurasawa, Satoko Arai, Y. Namiki, +5

Lara D. Veeken

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

Satoko Arai, Kento Kitada, Tomoko Yamazaki, +18

Nature Medicine

InflammationMedicineApoptosisAutophagyImmunology +11

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

Noelia A-González, José Ángel Guillén, Germán Gallardo, +16

Nature Immunology

InflammationMedicineFunctional SpecializationImmunologyImmunologic Mechanism +7

Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity

Jun Kurokawa, Satoko Arai, Katsuhiko Nakashima, +12

Cell Metabolism

InflammationLipid SynthesisBiochemistryAdipose TissueMetabolic Regulation +5

Anti-TIF1-γ antibody and cancer-associated myositis

Ayumi Hida, Takenari Yamashita, Yuji Hosono, +39

Neurology

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

Emiri Hiramoto, Akihisa Tsutsumi, Risa Suzuki, +4

Science Advances

Protein SecretionProtein AssemblyImmunologyMolecular BiologyImmunologic Mechanism +19

Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells

Satoko Arai, Natsumi Maehara, Yoshihiro Iwamura, +16

Cell Reports

ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityImmunotherapy +25

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Michito Hamada, Megumi Nakamura, Mai T. Tran, +18

Nature Communications

InflammationVascular DiseaseCardiovascular DiseaseImmunologyFoam-cell Apoptosis +6

Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue

Jun Kurokawa, Hiromichi Nagano, Osamu Ohara, +4

Proceedings of the National Academy of Sciences