Veeraswamy Manne

Discovery of <i>N</i>-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

Gretchen M. Schroeder, Yongmi An, Zhen‐Wei Cai et al. · Journal of Medicinal Chemistry · 2009 · 276 citations · Full text

Orally Efficacious Inhibitor, Drug Target, Pharmacotherapy +21

Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

Veeraswamy Manne, Eva Bekesi, H F Kung · Proceedings of the National Academy of Sciences · 1985 · 194 citations · Full text

Decreased Gtpase Activity, Gtpase Activity, Molecular Regulation +21

Identification and preliminary characterization of protein-cysteine farnesyltransferase.

Veeraswamy Manne, Daniel M. Roberts, Alyson K. Tobin et al. · Proceedings of the National Academy of Sciences · 1990 · 142 citations · Full text

Biosynthesis, Mevalonate Synthesis, Biochemistry +12

Discovery of (<i>R</i>)-7-Cyano-2,3,4,5-tetrahydro-1-(1<i>H</i>-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1<i>H</i>-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity

John T. Hunt, Charles Z. Ding, Roberta S. Batorsky et al. · Journal of Medicinal Chemistry · 2000 · 134 citations · Full text

Medicinal Chemistry, -1,4-Benzodiazepine Farnesyltransferase, Biochemistry +15

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

Veeraswamy Manne, Ning Yan, Carboni Jm et al. · PubMed · 1995 · 132 citations