Holly H. Soutter

Structural insight into allosteric modulation of protease-activated receptor 2

R.K. Cheng, Cédric Fiez-Vandal, Oliver Schlenker et al. · Nature · 2017 · 253 citations

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Amaury E. Fernández‐Montalván, Markus Berger, Benno Kuropka et al. · ACS Chemical Biology · 2017 · 91 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

John W. Cuozzo, Diana Gikunju, Sevan Habeshian et al. · ChemBioChem · 2017 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fragment‐Based Screen against HIV Protease

Alexander L. Perryman, Qing Zhang, Holly H. Soutter et al. · Chemical Biology & Drug Design · 2010 · 66 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17