Ryoko Hirakawa

A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias

Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 190 citations

Medicine, Cardiology, Pharmacology +17

Na_v1.5-dependent persistent Na⁺ influx activates CaMKII in rat ventricular myocytes and N₁₃₂₅S mice

Lina Yao, Peidong Fan, Zhan Jiang et al. · American Journal of Physiology-Cell Physiology · 2011 · 95 citations

Life Sciences, Cell Biology, Physiology +17

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late <i>I</i>_Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Jeff Zablocki, Elfatih Elzein, Xiaofen Li et al. · Journal of Medicinal Chemistry · 2016 · 34 citations · Full text

Medicine, Cardiology, Pharmacology +17

Ranolazine Reduces Neuronal Excitability by Interacting with Inactivated States of Brain Sodium Channels

Kristopher M. Kahlig, Ryoko Hirakawa, Lynda Liu et al. · Molecular Pharmacology · 2013 · 32 citations

Medicine, Neuroscience, Pharmacology +17

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine

Dmitry O. Koltun, Eric Q. Parkhill, Elfatih Elzein et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 30 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12