H. Adrian Bunzel

How directed evolution reshapes the energy landscape in an enzyme to boost catalysis

Renee Otten, R.A.P. Padua, H. Adrian Bunzel et al. · Science · 2020 · 186 citations · Full text

Engineering, Biochemistry, Evolutionary Biology +17

Evolution of dynamical networks enhances catalysis in a designer enzyme

H. Adrian Bunzel, J. L. Ross Anderson, Donald Hilvert et al. · Nature Chemistry · 2021 · 133 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold

Sophie Basler, Sabine Studer, Yike Zou et al. · Nature Chemistry · 2021 · 105 citations · Full text

Engineering, Biochemistry, Chemistry +14

Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme

H. Adrian Bunzel, Hajo Kries, Luca Marchetti et al. · Journal of the American Chemical Society · 2019 · 60 citations · Full text

Life Sciences, Biochemistry, Evolutionary Biology +17

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Christopher Fröhlich, H. Adrian Bunzel, Karol Buda et al. · Nature Catalysis · 2024 · 55 citations · Full text

Life Sciences, Evolutionary Biology, Molecular Biology +17