H. Adrian Bunzel

How directed evolution reshapes the energy landscape in an enzyme to boost catalysis

Renee Otten, R.A.P. Padua, H. Adrian Bunzel et al. · Science · 2020 · 177 citations · Full text

Protein Assembly, Molecular Biology, Bioenergetics +17

Evolution of dynamical networks enhances catalysis in a designer enzyme

H. Adrian Bunzel, J. L. Ross Anderson, Donald Hilvert et al. · Nature Chemistry · 2021 · 129 citations · Full text

Engineering, Biochemistry, Enzymes +10

Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold

Sophie Basler, Sabine Studer, Yike Zou et al. · Nature Chemistry · 2021 · 99 citations · Full text

Biosynthesis, Bioorganic Chemistry, Engineering +12

Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme

H. Adrian Bunzel, Hajo Kries, Luca Marchetti et al. · Journal of the American Chemical Society · 2019 · 58 citations · Full text

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Christopher Fröhlich, H. Adrian Bunzel, Karol Buda et al. · Nature Catalysis · 2024 · 44 citations · Full text