Sarah Frew

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

Benjamin N. Atkinson, David Steadman, Yuguang Zhao et al. · MedChemComm · 2019 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

William Mahy, Mikesh Patel, David Steadman et al. · Journal of Medicinal Chemistry · 2020 · 20 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

5-Phenyl-1,3,4-oxadiazol-2(3<i>H</i>)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

William Mahy, Nicky J. Willis, Yuguang Zhao et al. · Journal of Medicinal Chemistry · 2020 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

Nicky J. Willis, William Mahy, James Sipthorp et al. · Journal of Medicinal Chemistry · 2022 · 17 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structural Insights into Notum Covalent Inhibition

Yuguang Zhao, Fredrik Svensson, David Steadman et al. · Journal of Medicinal Chemistry · 2021 · 16 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +15