Development of a microphysiological model of human kidney proximal tubule function

Elijah J. Weber, Alenka Chapron, Brian D. Chapron, +12

Kidney International

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

Jingjing Jiang, Lingyan Jiang, Benjamin J. Maldonato, +34

Cancer Discovery

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

Christopher J. Schulze, Kyle J. Seamon, Yulei Zhao, +33

Science

An Inducible Cytochrome P450 3A4-Dependent Vitamin D Catabolic Pathway

Zhican Wang, Yvonne S. Lin, Xi Zheng, +10

Molecular Pharmacology

Simultaneous measurement of plasma vitamin D3 metabolites, including 4β,25-dihydroxyvitamin D3, using liquid chromatography–tandem mass spectrometry

Zhican Wang, Tauri Senn, T F Kalhorn, +6

Analytical Biochemistry

Vitamin NutritionMedicineBioanalysisMass Spectrometry4β,25-Dihydroxyvitamin D3 +5

Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease

David A. Jolliffe, Christos Stefanidis, Zhican Wang, +14

American Journal of Respiratory and Critical Care Medicine

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

Bianca J. Lee, Jacob A. Boyer, G. Leslie Burnett, +23

Nature Chemical Biology

Tumor BiologyMedicinePharmacologySuppress Tumor GrowthAnti-cancer Agent +4

Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia

Zhican Wang, Yvonne S. Lin, Leslie J. Dickmann, +7

Journal of Bone and Mineral Research

Characterizing Antibody Cross-reactivity for Immunoaffinity Purification of Analytes prior to Multiplexed Liquid Chromatography–Tandem Mass Spectrometry

Thomas J. Laha, Frederick G. Strathmann, Zhican Wang, +3

Clinical Chemistry

Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability

Zhican Wang, Timothy C. Wong, Takanori Hashizume, +8

Endocrinology

Human Ugt1a4Redox BiologyInterindividual VariabilityCarbonyl MetabolismOxidative Stress +14